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Glucosamine is found naturally in the body, within the joints and connective tissue, and is made up of a combination of protein and sugar. Chondroitin Sulphate is also found naturally in the body in and around cartilage cells. When the two substances are combined they form Glucosamine Sulphate. As the two ingredients that make up Glucosamine Sulphate are essential elements for the healthy function of the joints, it is often used to ease the discomfort caused by osteoarthritis. Osteoarthritis can be a very painful condition which can damage cartilage; result in bony growths around the joints and also cause mild inflammation of the joint tissue. The NHS estimates that around 8.5 million people in the UK currently suffer from the condition. Glucosamine sulphate is said to be effective against osteoarthritis and has been approved for prescription by some European Union countries. Several medical trials have found that glucosamine sulphate is more effective than a placebo in improving movement range and easing joint pain caused by osteoarthritis[1]. However, some medics in the UK and US have expressed caution over possible bias in the medical trials which looked at Glucosamine Sulphate in the relief of joint conditions[2]. This is because some of the trials were sponsored by large pharmaceutical companies, were not on a large enough scale or contained poor quality research. In the UK, glucosamine sulphate is not prescribed but is commonly sold as a nutritional supplement to aid the healthy development of tendons, muscles and cartilage. Some believe that it can help protect against the aging process where joints degenerate and range of movement becomes restricted. Doctors and qualified nutritionists should be able to advise those considering the supplement whether it is suitable for them. [1] Rovati L C, et al (1999). Correspondence: Glucosamine in osteoarthritis. Lancet; 354 (6): 1641-1642 [2] Braham R, Dawson B, Goodman C (2003). The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine; 37:45-49.